Major Depressive Disorder with Mixed Features – A Rapid Review

Posted on:June 28, 2020
Last Updated: June 28, 2020
Time to read: 3 minutes

Depressive disorder with mixed features (DMX), also known as a mixed episode, a mixed state or agitated depression, is a term used in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to describe a condition in which the symptoms of mania or sub-syndromal mania occur during the depressive disorders of either Major Depressive Disorder or Bipolar I or II disorder.

The disorder can be conceptualised as lying at the cusp between depression and mania.

Currently, only one treatment guideline exists for major depressive episode with mixed features (i.e., the Florida Best Practice Psychotherapeutic Medication Guidelines for Adults [2015], available for download here.

In this article, we summarise the recent guidelines published by Stahl S et al 2017.