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  •  Dr Sanil Rege
    June 17, 2022
    Time to read: 10 minutes

    Brexpiprazole – Psychopharmacology | Mechanism of Action | Clinical Application

    Brexpiprazole [7-{4-[4-(1-benzothiophene-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one] is a novel atypical antipsychotic that is structurally similar ...

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  •  Dr Sanil Rege
    June 3, 2022
    Time to read: 4 minutes

    Making Sense of Clozapine Levels – Clinical Application | Clozapine – NorClozapine Ratio | Side Effects

    Clozapine is metabolised in the liver predominantly by CYP1A2 and partially (35% ) by CYP3A4. It is, however, important to recognise that in some patien...

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  • May 31, 2022

    Dopamine Pathways in Schizophrenia – Q & A Session with the Experts

    Dr Sanil Rege is a Consultant Psychiatrist with dual psychiatry qualifications from the United Kingdom and Australia. He is the founder of Psyc...

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  • May 26, 2022

    Beyond Dopaminergic Dysfunction – Are There Now Two Distinct Types of Schizophrenia? Presented by Prof David Castle

    Prof David Castle is a Professor of Psychiatry at St Vincent’s Health Centre (Victoria) and The University of Melbourne. His clinical and research int...

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  • May 26, 2022

    Dopamine Receptor Pathways, Functions and Actions – Prof David Castle

    Prof Castle is the inaugural Scientific Director of the Centre for Complex Interventions at Centre for Addictions and Mental Health (CAMH), University o...

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  • May 25, 2022

    The Impact of Substance Abuse In Schizophrenia Presented by Prof David Castle

    Prof David Castle is a Professor of Psychiatry at St Vincent’s Health Centre (Victoria) and The University of Melbourne. His clinical and research int...

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  •  Dr Sanil Rege, Prof David Castle
    April 7, 2022
    Time to read: 21–25 minutes

    Antipsychotic Induced Weight Gain and Metabolic Dysfunction – A Review of Pathophysiology and Management Strategies

    Obesity is a critical public health problem predictive of the development of cardiovascular disease, metabolic syndrome,...

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  •  Dr Sanil Rege
    December 17, 2021
    Time to read: 11–13 minutes

    Paliperidone Long Acting Injections (Sustenna / Trinza / Hafyera) – Psychopharmacology and Clinical Application

    Paliperidone long-acting injections (LAIs) are available in three forms (1 monthly, 3 monthly and 6 monthly injectable forms). All three forms contain a...

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  •  Dr Sanil Rege
    November 23, 2021
    Time to read: 11–14 minutes

    Clozapine Induced Constipation and Gastrointestinal Hypomotility (CIC & CIGH) – Case Report and Summary of Management Principles

    Constipation is a common side effect of clozapine and may cause death if severe. Unlike agranulocytosis and myocarditis, clozapine’s effects on bowel ...

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  •  Dr Sanil Rege
    October 16, 2021
    Time to read: 7 minutes

    Antipsychotic Withdrawal Syndrome – Understanding the Hyperbolic Curve and Tapering Antipsychotic Treatment to Reduce the Risk of Relapse

    We previously covered antidepressant withdrawal. Antipsychotic withdrawal can pose similar challenges. Despite the challenges...

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