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  •  Dr Sanil Rege
    April 26, 2022
    Time to read: 11–13 minutes

    Review of Lithium-Induced Renal Dysfunction – Pathophysiology | Diagnosis | Management

    Lithium-induced nephropathy has been reported since the 1970s and covers many kidney function impairments. ...

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  •  Dr Sanil Rege, Prof David Castle
    April 7, 2022
    Time to read: 21–25 minutes

    Antipsychotic Induced Weight Gain and Metabolic Dysfunction – A Review of Pathophysiology and Management Strategies

    Obesity is a critical public health problem predictive of the development of cardiovascular disease, metabolic syndrome,...

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  •  Dr Sanil Rege
    March 20, 2022
    Time to read: 5 minutes

    Psychopharmacology and Clinical Application of Guanfacine and Clonidine for ADHD – What’s the Difference?

    Psychostimulants are first-line treatments for ADHD. However, some patients may be resistant to treatment or may not tolerate stimulants. Alpha-2...

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  •  Dr Sanil Rege
    March 19, 2022
    Time to read: 15–18 minutes

    Neurosteroids in Psychiatry – Pharmacology | Mechanisms of Action | Clinical Application

    Neurosteroids or Neuroactive Steroids (NAS) are endogenous steroid hormones synthesised from cholesterol in the mitochondria of glial cells or from ster...

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  •  Dr Sanil Rege
    March 13, 2022
    Time to read: 16–19 minutes

    Venlafaxine (Effexor) and Desvenlafaxine (Pristiq) – Mechanism of Action | Differences | Psychopharmacology | Clinical Application

    Venlafaxine (EFFEXOR) is a serotonin and noradrenaline reuptake inhibitor (SNRI) that is indicated for major depressive disorder (MDD), generalised anxi...

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  • January 27, 2022

    Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) – Mechanism of Action

    Serotonin-noradrenaline reuptake inhibitors (SNRIs) are evidence-based medications in treating ...

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  •  Dr Sanil Rege
    December 17, 2021
    Time to read: 11–13 minutes

    Paliperidone Long Acting Injections (Sustenna / Trinza / Hafyera) – Psychopharmacology and Clinical Application

    Paliperidone long-acting injections (LAIs) are available in three forms (1 monthly, 3 monthly and 6 monthly injectable forms). All three forms contain a...

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  •  Dr Sanil Rege
    November 23, 2021
    Time to read: 11–14 minutes

    Clozapine Induced Constipation and Gastrointestinal Hypomotility (CIC & CIGH) – Case Report and Summary of Management Principles

    Constipation is a common side effect of clozapine and may cause death if severe. Unlike agranulocytosis and myocarditis, clozapine’s effects on bowel ...

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  • November 15, 2021

    Lamotrigine Induced Rash – Assessment and Management by Dr. Sanil Rege

    In this video, Dr Sanil Rege discusses the nature of rashes that occur with Lamotrigine and outlines an algorithm for how to a...

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  • November 3, 2021
    Time to read: 4 minutes

    Mechanism of Action of Selective Serotonin Reuptake Inhibitors (SSRIs) – The Latest

    The serotonergic hypothesis of depression postulated that diminished activity of serotonin pathways plays a causal role in the pathophysiology of depres...

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