What’s Different about Agomelatine’s Mechanism of Action – Prof Hopwood and Dr Stephen Stahl
Dr Stahl, MD, is a practicing Psychiatrist in Carlsbad, USA, and author of the best-selling textbook, Essential Psychopharmacology. Dr Stahl has held faculty positions at Stanford University, the University of California at Los Angeles, the Institute of Psychiatry London, the Institute of Neurology London, and, currently, at the University of California at San Diego.
Prof. Hopwood is the Ramsay Health Care Professor of Psychiatry at the University of Melbourne. His research areas of interest include psychopharmacology, clinical aspects of mood and anxiety disorders and psychiatry aspects of acquired brain injury and other neuropsychiatric disorders
Take Home Messages
- Agomelatine stimulates two melatonin receptors and blocks serotonin (5HT) 2C receptors.
- Agomelatine increases dopamine and norepinephrine levels in the brain.
- Agomelatine synchronises circadian rhythms.
- In animal models, it has been shown to increase neurotrophic factors like brain derived neurotrophic factor (BDNF).
Read the mechanism of action, side effect profile, dosing and efficacy studies in detail. Agomelatine also was featured in the largest ever network meta-analysis (NMA) by Cipriani.