Video on Understanding Schizophrenia – Linking Neurobiology to Clinical Features

Posted on: May 6, 2020
Last Updated: November 20, 2021

In this Hub Bite video, Dr Sanil Rege deconstructs Schizophrenia and covers the main neurobiological pathways that mediate clinical symptoms.

Antipsychotic medications act on the D2 receptors and reduce psychotic symptoms. However, their D2 blocking activity in other pathways can be associated with side effects. By examining these pathways independently, one can take a comprehensive view of the patient linking both mind and body.

The video also shows videos of patients with EPSE’s and shows the Luria three-step test to examine cognition (frontal lobe). Frontal lobe in psychiatry

Main aspects covered:

1. Dopamine metabolism
2. Dopamine receptors
3. Dopamine pathways in the brain
4. Role of pathways
5. Role of the 5HT2A antagonism of antipsychotic medications
6. Side effects of antipsychotics

Learn More:

  1. Dopamine Hypothesis of Schizophrenia
  2. Simplified guide to antipsychotic medications
  3. Extrapyramidal side effects of antipsychotics