Q & A Session on Neuroinflammation in Psychiatry – Dr. Sanil Rege

Posted on: July 24, 2020
Last Updated: July 25, 2020

Dr. Sanil Rege is a Consultant Psychiatrist and founder of Psych Scene, a platform to enhance psychiatry education and Vita Healthcare, providing high quality mental health care services to the public. He is a Fellow of the Royal Australian and New Zealand College of Psychiatrists and Member of the Royal College of Psychiatrists (UK). His clinical and research interests include psychosis, depression, anxiety, post-traumatic stress disorders, and personality disorders. 

 Author Quotes  

There have been trials that have looked at Omega-3 in the prevention of recurrent miscarriages in antiphospholipid syndrome (APS). So, if we’re looking at a similar mechanism – if we’re looking at placental circulation and cerebral circulation being affected the same way – then highly likely [that Omega-3 is a rational strategy in APS]. 

The question is whether we need a Consensus Working Party for these so-called ‘rare’ disorders, because with that there may be further discussions and we might actually be able to go forward with research. 

Summary  

The session starts with a discussion of how clinical trials have now evaluated omega 3 in the prevention of miscarriages in antiphospholipid syndrome (APS). The questions continue with a discussion on how different infections can cause the body to produce antiphospholipid antibodies and how GPs and specialists deal with patient management.  

The Q&A sessions ends with a look at how drugs with a multifactorial mechanism such as valproate may be highlighting a link between specific symptoms and/or conditions such as epilepsy, migraine and cyclical mood disorders. 

Take Home Points 

  • The autoimmune system may be triggered by different infections to produce antiphospholipid antibodies (molecular mimicry) but these tend not to be pathogenic. 
  • Patients with severe multifocal lesions and valvular lesions require anticoagulation with warfarin rather than aspirin. 
  • Medical evaluation requires referral of patients to specialists who will keep an open mind. 

Quiz

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