Navigating a Case of Treatment-Resistant Depression (TRD) in Clinical Practice

Posted on: July 18, 2022
Last Updated: December 28, 2022

The term treatment-resistant depression (TRD) is problematic because it has been associated with a narrow focus on pharmacotherapeutic non-response and also because it invokes a nihilistic view regarding managing depression.

To overcome these problems the term difficult-to-treat depression (DTD) has been proposed with two main advantages,

  • ‘Difficult to treat’ suggests that the management of the depressive illness is likely to be challenging, but at the same time, it is not unachievable.
  • The definition of DTD is not predicated on pharmacotherapy alone, and the management of DTD involves a much broader set of strategies – including, for example, psychosocial measures.

This video covers the following:

  1. Difference between Treatment-resistant depression and Difficult to treat depression
  2. Navigating a clinical case of TRD / DTD by using the diagnostic hierarchy

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