N-Acetylcysteine (NAC): An Overlooked Agent in Psychiatric Treatment?

N-acetylcysteine (NAC), traditionally used in respiratory and toxicological medicine, has garnered interest in psychiatry for its potential in addressing oxidative stress, neuroinflammation, and glutamatergic dysfunction. In this video, Dr Sanil Rege explores the evolving evidence for NAC as an adjunct in managing psychiatric disorders such as schizophrenia, depression, bipolar disorder, OCD, and substance use disorders.

Through a detailed breakdown of NAC’s mechanisms—including its effects on glutathione, cytokine modulation, and mitochondrial protection—Dr Rege examines how this supplement may influence symptom domains and neurobiological pathways. He also discusses dosing strategies, clinical trial findings, safety considerations, and current limitations, offering a nuanced perspective on its practical application in mental health care.