Mechanisms of Sexual Dysfunction with Antidepressants – Conversations with Prof Anita Clayton

Posted on July 28, 2017

This is the second video as part of a series of brief interviews with Prof Anita Clayton focusing on sexual function and antidepressants. Prof Clayton’s clinical practice and research interests focus on women’s mental health and sexual dysfunctions. She is the David C. Wilson Professor and Chair of the Department of Psychiatry and Neurobehavioral Sciences, with a secondary appointment as professor of clinical obstetrics and gynecology. She is board certified in psychiatry and neurology.

Take Home Messages:

  • We have inhibitory mechanisms and excitatory mechanisms related to sexual activity
  • Serotonin tends to be an inhibitor of sexual function
  • Dopamine and Nor-epinephrine are excitatory neurotransmitters

If you use an SSRI, you are getting more serotonin everywhere and more inhibition of all the phases of the sexual response cycle (desire, arousal, orgasmic function and pleasure)

  • Drugs that antagonise 5HT2C are less likely to lead to sexual side effects. e.g Agomelatine, Mirtazapine

You can view the first video about the importance of assessing sexual function in patients on AD’s.


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