Prof. Graham Hughes trained at the London Hospital and spent two years with Prof. Charles Christian in New York working on the introduction of the anti-DNA assay. He set up Europe’s first dedicated Lupus clinic in 1971 and described the Antiphospholipid syndrome / Hughes Syndrome in 1983.  He is the founder and editor of the International Journal Lupus, now in its 20th year. Prof Hughes has published widely in Lupus and connective tissue diseases and published 12 books. He is head of the London Lupus Centre at London Bridge hospital in London. He delivers an introduction to two diseases: Lupus and Hughes Syndrome (antiphospholipid syndrome, APS). Future videos will showcase these diseases in more detail.

1. Osler was the first clinician to put Lupus on the map in 1895 – “….of unknown aetiology….skin lesions, arthritis, gastrointestinal crises, endocarditis, pericarditis, acute nephritis….recurrence is a special feature of the disease…”
2. “So doctor, do you have any patients with hair loss, fatigue, rashes, recurrent Glandular Fever and/or M.E? These are all symptoms of Lupus”
3. In order to test for Lupus, Prof. Hughes suggests that you tick three boxes: 1. ANA, 2. DNA (absolute) and 3. Anticardiolipin (aCL) (For the antiphospholipid syndrome)

Video of a clinical case of Antiphospholipid syndrome with neuropsychiatric manifestations. 

Quiz

Learn more

1. Antiphospholipid Syndrome (APS) Case Files (Stroke and Thrombosis) By Prof Graham Hughes
2. Antiphospholipid Syndrome (APS) Case Files (Stillbirths and Epilepsy) By Prof Graham Hughes
3. Antiphospholipid Syndrome (APS) Case Files (Gut, Tinnitus, and Migraine) – Prof Graham Hughes
4. Antiphospholipid Syndrome (APS): The Clinical Experience – Dr. Graham Hughes
5. Antiphospholipid Syndrome: 30 Years On – Dr. Graham Hughes
6. Central Nervous System (CNS) Involvement in Antiphospholipid (Hughes) Syndrome – Prof Graham Hughes
7. Clues to the Diagnosis of Antiphospholipid Syndrome – Prof Graham Hughes
8. Neuropsychiatric Lupus and The Curious Case of Molly – What Does This Case Teach Us? – Prof Hughes
9. Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus – Prof Graham Hughes
10. What is Lupus? – Prof Graham Hughes
11. APS and CNS Lupus: Anticoagulation Treatment By Prof Graham Hughes
12. Neuropsychiatric Manifestations in APS By Prof Graham Hughes
13. Q & A session on Lupus, Hughes Syndrome and the Brain – Prof Hughes