How To Appraise A Systematic Review and Meta Analysis in Clinical Practice- Dr Sanil Rege
A systematic review is a comprehensive review of primary studies addressing a clearly formulated question using systematic and explicit methods to identify, select and critically appraise relevant research. Meta-analysis is the mathematical synthesis of the primary studies in a systematic review to give a pooled estimate of effect size.
Advantages of systematic reviews and meta-analyses
• Explicit methods are used in identifying and excluding studies based on strict inclusions and exclusions criteria. This limits bias.
• It increases the power of the study by combining different studies, thus increasing the probability of finding a truly significant effect and reducing type II error, i.e. false negative. (This is mainly through a meta-analysis, i.e. quantitative systematic review)
• Large amounts of information can be assimilated quickly by healthcare providers, researchers, and policymakers.
• Prevents or reduces the delay between research discoveries and the implementation of effective diagnostic and therapeutic strategies.
• The results of different studies can be formally compared to establish generalisability of findings and consistency of results.
• Reasons for heterogeneity (inconsistencies) can be identified, and a new hypothesis can be generated for different subgroups.
• It allows for a more objective appraisal of evidence and a more reliable and accurate result due to the methods used.
• Promising research questions to be addressed in future studies may be generated, and the sample size needed in future studies may be calculated accurately.
- The Neurobiology of Trauma and PTSD Phenotypes – Dr Sanil Rege
- Clozapine Mechanism of Action and Augmentation Strategy – Dr Sanil Rege
- Pathogenesis and Diagnostic Indicators for Antiphospholipid Syndrome (APS) in Psychiatry-Dr Sanil Rege
- Antiphospholipid Syndrome and the Brain (Neuropsychiatric Manifestations of APS) – Dr Sanil Rege
- Techniques to Prepare For the EMQ and Critical Analysis (MCQ) Problems – RANZCP Written Exam-Dr Sanil Rege
- Passing the Modified Essay (MEQ) and Critical Essay (CEQ) Exam- RANZCP- Dr Sanil Rege
- Essential Mental Models for A Psychiatrist – The Art of Complex Problem Solving- Dr Sanil Rege
- Observed Clinical Activity (OCA) and MEQ – Passing the RANZCP Exam- Dr Sanil Rege
- Sanil Rege on Education and Entrepreneurship – Podcast
- A Summary of 3 Important Autoimmune Neuropsychiatric Disorders for Psychiatrists – Dr Sanil Rege
- Neuroinflammation Simplified – The Link Between the Immune System and The Brain- Dr Sanil Rege
- Q & A Session on Neuroinflammation in Psychiatry – Dr. Sanil Rege
- What is Regression Analysis in Critical Appraisal? – Dr Sanil Rege
- Principles of Entrepreneurship and Innovation in Medicine – Dr Sanil Rege
- The Power of Serendipity and Multidisciplinary Learning in Medicine – Solving a Complex Clinical Case- Dr Sanil Rege
- Psychiatric Formulation and Management- Tips and Techniques- Dr Sanil Rege
- Psychiatry Exams – What’s the Right Mindset?- Dr Sanil Rege
- Psychiatry Trainee to Consultant Psychiatrist – Skills Breakdown- Dr Sanil Rege
- From Psychiatry Trainee to Consultant Psychiatrist – Stages of Training for the RANZCP Exams- Dr Sanil Rege
- From Psychiatry Trainee to Consultant Psychiatrist- Dr Sanil Rege