The Neuroscience of Fasting: Cognitive and Mental Health Effects Explored

In this video, Dr Sanil Rege, consultant psychiatrist, explores the compelling science behind fasting and brain health, drawing on evolutionary biology to explain how intermittent fasting enhances cognitive function. Through the lens of our ancestral physiology, he demonstrates how metabolic switching—from glucose to ketones—supports cognitive performance, neuroplasticity, and resilience.

The video examines key mechanisms, including BDNF, mitochondrial biogenesis, and autophagy, offering practical insights into how fasting may optimise brain function and protect against cognitive decline. This evidence-informed exploration of fasting and brain health provides valuable knowledge for clinicians and mental health professionals.

Key topics covered:

1. Metabolic switching: How fasting shifts the brain from glucose to ketones
2. BDNF & neuroplasticity: The brain’s natural fertiliser for learning & memory
3. Mitochondrial biogenesis: How fasting upgrades brain energy efficiency
4. Autophagy: The brain’s built-in clean-up system for long-term health
5. Intermittent fasting strategies: How to optimise cognitive performance