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  •  Dr Sanil Rege
    December 17, 2021
    Time to read: 11–13 minutes

    Paliperidone Long Acting Injections (Sustenna / Trinza / Hafyera) – Psychopharmacology and Clinical Application

    Paliperidone long-acting injections (LAIs) are available in three forms (1 monthly, 3 monthly and 6 monthly injectable forms). All three forms contain a...

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  •  Dr Sanil Rege
    November 23, 2021
    Time to read: 11–14 minutes

    Clozapine Induced Constipation and Gastrointestinal Hypomotility (CIC & CIGH) – Case Report and Summary of Management Principles

    Constipation is a common side effect of clozapine and may cause death if severe. Unlike agranulocytosis and myocarditis, clozapine’s effects on bowel ...

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  •  Dr Sanil Rege
    October 16, 2021
    Time to read: 9 minutes

    Antipsychotic Withdrawal Syndrome – Understanding the Hyperbolic Curve and Tapering Antipsychotic Treatment to Reduce the Risk of Relapse

    We previously covered antidepressant withdrawal. Antipsychotic withdrawal can pose similar challenges. Despite the challenges...

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  •  Dr Sanil Rege
    September 21, 2021
    Time to read: 11–13 minutes

    Psychopharmacology and Clinical Application of Aripiprazole Long Acting Injections – Review of Abilify Maintena & Aristada

    Aripiprazole long-acting injections (LAIs) come in two forms – Abilify Maintena and Aristada. This article covers the psychopharmacology of Aripip...

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  • September 13, 2021
    Time to read: 7 minutes

    Synaptic Pruning and Schizophrenia – Role of Microglia and Future Directions

    Synaptic pruning is an important developmental process that refines and optimises neuronal transmission. ...

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  •  Dr Sanil Rege
    August 14, 2021
    Time to read: 5 minutes

    Impact of Smoking on Clozapine Levels – Management of Smoking Cessation in Clozapine Treatment

    Smoking affects Clozapine levels. Re...

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  •  Dr Sanil Rege
    April 11, 2021
    Time to read: 12–15 minutes

    Cariprazine – Mechanism of Action | Psychopharmacology | Clinical Application

    Cariprazine is an atypical antipsychotic medication with a unique pharmacological profile and various clinical applications. It is a dopamine D3/...

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  • March 25, 2021
    Time to read: 10 minutes

    Clozapine Augmentation in Clozapine Resistant Schizophrenia – Quick Review – 2023 Update

    Up to 30% of patients with schizophrenia are classed as non-responders to antipsychotics. ...

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  •  Dr Sanil Rege, Prof David Castle, Prof Nagesh Pai, Dr Frances Dark
    February 13, 2021
    Time to read: 21–25 minutes

    Negative Symptoms in Schizophrenia – A Review of Neurobiology, Diagnosis and Management

    Schizophrenia is a complex, chronic disorder characterised by a constellation of positive and negative symptoms.  While clinical practice and therapeut...

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  • January 9, 2021

    Akathisia – Pathophysiology, Diagnosis and Management Strategies

    Dr Sanil Rege is a Consultant psychiatrist, founder of Psychscene.com and ...

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