Psych Scene Hub

PSYCHOPHARMACOLOGY

A Focus on Vortioxetine – Mechanism of Action and Efficacy

Traditionally, antidepressant research has focused on the development of drugs that bind to the serotonin transporter (SERT). SERT transports serotonin from the synaptic cleft to the presynaptic neuron and inhibition of this transporter causes an increase in serotonin in the synaptic cleft.   However, many…
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A Focus on Agomelatine – Mechanism of Action and Efficacy

Agomelatine is a melatonin receptor agonist and a serotonin receptor antagonist with a favourable side effect profile. There is a lack of sexual dysfunction, sleep benefits, and no discontinuation symptoms – all of which confer valuable clinical benefits in the treatment of depression [2]. Agomelatine exerts…
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Emotional Blunting with SSRI’s – Prof Malcolm Hopwood

Prof. Hopwood is the Ramsay Health Care Professor of Psychiatry at the University of Melbourne. His research areas of interest include psychopharmacology, clinical aspects of mood and anxiety disorders and psychiatry aspects of acquired brain injury and other neuropsychiatric disorders. Take Home Messages: SSRI’s are…
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The Neurobiological Basis of Addiction – From Choice to Habit to Compulsion

Researchers used male Lister Hooded rats that underwent functional disconnections (by excitotoxic lesions) of the amygdala-striatal networks, combined with cocaine self-administration training sessions. Measurements at different stages (early, intermediate and late) of goal-directed, cue-controlled cocaine-seeking behaviour were analysed to understand the effect of disconnections on…
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How Effective Are Contemporary Antidepressants? – Prof Malcolm Hopwood

Prof. Hopwood is the Ramsay Health Care Professor of Psychiatry at the University of Melbourne. His research areas of interest include psychopharmacology, clinical aspects of mood and anxiety disorders and psychiatry aspects of acquired brain injury and other neuropsychiatric disorders. The most recent meta-analysis looking…
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