A Focus on Vortioxetine – Mechanism of Action and Efficacy

Posted on October 27, 2017
Time to read: 5 minutes

Vortioxetine is an atypical antidepressant with multimodal activity. It is a serotonin modulator and stimulator because although it has SERT inhibition properties, it is also a serotonin receptor agonist and antagonist.

It also exerts effects on norepinephrine, dopamine, glutamate, GABA, and the cholinergic system.


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  • Dr Akram Yousif

    Thanks for the useflul article, the only thing that puzzled me was the fact it causes sexual dysfunction? as far as i am concerned it is one of the few medication that can be recommended for patients with sexual dysfunction! wish if someone can shed more light on this subject, thanks

    • Psychscenehub

      Hi , We have just added a section on the sexual dysfunction for vortioxetine. in the initial trials the high placebo rate may indicate a base effect in patient group. Subsequent reviews have stated a lower incidence of SD. Certainly clinically it is one of the meds to be used in context of SSRI or SNRI induced sexual dysfunction. Agomelatine, bupropion or mirtazapine are others.

      ” In an analysis of seven placebo-controlled trials, sexual dysfunction
      was reported by up to a third of men and women taking the 15 mg or 20
      mg dose. Sexual problems were, however, also reported in up to 20% of
      people taking the placebo. (NPS)

      An April 2017 paper stated that sexual dysfunction with vortioxetine was not statistically higher when compared with placebo, and was statistically lower compared with other SSRIs or SNRIs.
      They also stated that there is evidence that antidepressants that are
      also 5HT-1A receptor agonists (e.g., vortioxetine and vilazodone) may
      facilitate sexual performance.”

  • jaycdp

    The setrans are also an antogonist of 5ht3, in that case it should also be an anti emetic ( vortioxetin is a potent inhibitor on 5t3 receptar)