Revisiting Tricyclic Antidepressants: Understanding the Differences and Advantages for Effective Depression Treatment

Posted on:April 17, 2023
Last Updated: June 12, 2023
Time to read: 13–15 minutes

While newer antidepressant medications have gained popularity in recent years, tricyclic antidepressants (TCAs) remain an essential treatment option for depression.

Tricyclic antidepressants are first-generation antidepressants that are commonly used to treat Major depressive disorder (MDD), obsessive–compulsive disorder (OCD), and chronic pain (off-label).

Whilst selective serotonin reuptake inhibitors are generally recommended as first-line treatment for MDD, TCAs are often used when patients exhibit a non-response to newer-generation antidepressants.

However, not all TCAs are the same, and clinicians must understand their differences and advantages to treat their patients effectively.

This article will revisit TCAs and explore their pharmacological properties, efficacy, and side effect profiles.

By understanding the unique benefits of each TCA, clinicians can make informed decisions and improve outcomes for their patients with depression.

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