Does the Thyroid Gland Play a Role in Depression, Anxiety and Psychosis? – Is the TSH enough to diagnose thyroid dysfunction?

Posted on:January 6, 2016
Last Updated: February 11, 2020
Time to read: 6 minutes

I saw a 24 year old male who was admitted for increasing feelings of low mood and thoughts of suicide. On assessment, he showed symptoms of severe depression with no psychosis. Further investigations revealed a TSH of 5.5 and a normal T4 and T3.


High Dose Thyroxine Augmentation in Treatment Resistant Depression
Bauer, M., Hellweg, R., Gräf, K. J., & Baumgartner, A. (1998). Treatment of refractory depression with high-dose thyroxine. Neuropsychopharmacology, 18(6), 444-455.
Thyroxine Augmentation in Female Depressed Patients

Łojko, D., & Rybakowski, J. K. (2007). L-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. Journal of affective disorders, 103(1), 253-256.

Thyroid, Serotonin and the Brain
Bauer, M., A. Heinz, and P. C. Whybrow. “Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain.” Molecular psychiatry 7, no. 2 (2002).