Switching or Augmentation Strategies in the Treatment of Major Depressive Disorder – What Does the Evidence Tell Us?

Posted on:July 25, 2022
Last Updated: November 24, 2023
Time to read: 18–21 minutes

When patients with Major Depressive Disorder (MDD) don’t respond to medication, clinicians have three options: Increase dose, switch or augment.

Switching seems to be the favoured strategy, with 85% of psychopharmacologists endorsing switching and 11% endorsing augmentation in one study. [Goldberg et al ., 2015]

However, there is no clear consensus about the most optimal strategy.

In this article, we examine the evidence for switching vs augmentation strategies in managing major depressive disorder after an initial non-response to AD.