Ketamine and Esketamine in Depression – A Synopsis on Efficacy and Mechanism of Action

Posted on:July 15, 2016
Last Updated: November 25, 2023
Time to read: 7 minutes

Unipolar major depressive disorder (MDD) affects approximately 350 million people worldwide with almost one-third of patients not responding to existing anti-depressants.

Most antidepressants take weeks or months to achieve a significant effect thus highlighting a clear unmet need for rapid-acting and effective treatments.

For a detailed account of depression and antidepressants you can read:

  1. Clinical Management of Depression – Summary of RANZCP Guidelines
  2. Mechanisms of action of antidepressants