Ketamine and Esketamine in Depression – A Synopsis on Efficacy and Mechanism of Action
Unipolar major depressive disorder (MDD) affects approximately 350 million people worldwide with almost one-third of patients not responding to existing anti-depressants.
Most antidepressants take weeks or months to achieve a significant effect thus highlighting a clear unmet need for rapid-acting and effective treatments.
For a detailed account of depression and antidepressants you can read:
- Clinical Management of Depression – Summary of RANZCP Guidelines
- Mechanisms of action of antidepressants