Neuroinflammation and Depression – A Simplified Guide
A novel and emerging framework describes the involvement of neuroinflammation and the immune system in the pathophysiology of depression.
The PATHOS-D hypothesis states that depressive symptoms are components of the immune system that promote pathogen defence. [Raison and Miller, 2013]
We recommend this article is read in combination with the following articles to get a comprehensive overview of neuroinflammation in psychiatry and its relevance to clinical practice.
- Chronic Fatigue Syndrome | Myalgic Encephalomyelitis – Neurobiology | Diagnosis | Management
- The Neuropsychiatry of Long COVID and Post-Acute COVID-19 Syndrome: A Review
- Psychiatric and Neuropsychiatric Manifestations of COVID 19 – SARS-CoV-2 and the Brain
- The Neuropsychiatry of Fibromyalgia – Etiology and Management
Köhler CA, Freitas TH, Stubbs B, Maes M, Solmi M, Veronese N, de Andrade NQ, Morris G, Fernandes BS, Brunoni AR, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF. Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis. Mol Neurobiol. 2018 May;55(5):4195-4206.