Neuroinflammation and Depression – A Simplified Guide

Posted on:December 19, 2021
Last Updated: November 29, 2023
Time to read: 12–15 minutes

A novel and emerging framework describes the involvement of neuroinflammation and the immune system in the pathophysiology of depression.

The PATHOS-D hypothesis states that depressive symptoms are components of the immune system that promote pathogen defence. [Raison and Miller, 2013]

We recommend this article is read in combination with the following articles to get a comprehensive overview of neuroinflammation in psychiatry and its relevance to clinical practice.

  1. Chronic Fatigue Syndrome | Myalgic Encephalomyelitis – Neurobiology | Diagnosis | Management
  2. The Neuropsychiatry of Long COVID and Post-Acute COVID-19 Syndrome: A Review
  3. Psychiatric and Neuropsychiatric Manifestations of COVID 19 – SARS-CoV-2 and the Brain
  4. The Neuropsychiatry of Fibromyalgia – Etiology and Management