Inflammation and Depression – A Simplified Guide
A novel and emerging framework describes the involvement of inflammation and the immune system in the pathophysiology of depression.
The PATHOS-D hypothesis states that depressive symptoms are components of the immune system that promote pathogen defence. [Raison and Miller, 2013]
Köhler CA, Freitas TH, Stubbs B, Maes M, Solmi M, Veronese N, de Andrade NQ, Morris G, Fernandes BS, Brunoni AR, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF. Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis. Mol Neurobiol. 2018 May;55(5):4195-4206.