Psychopharmacology and Clinical Application of Guanfacine and Clonidine for ADHD – What’s the Difference?
Psychostimulants are first-line treatments for ADHD. However, some patients may be resistant to treatment or may not tolerate stimulants.
Alpha-2 adrenergic agonists, guanfacine and clonidine can be valuable as monotherapy or augmentation agents in ADHD.
Both clonidine and guanfacine stimulate Alpha-2 adrenergic receptors pre and post-synaptically.