Psychopharmacology and Clinical Application of Guanfacine and Clonidine for ADHD – What’s the Difference?

Posted on:March 20, 2022
Last Updated: April 28, 2022
Time to read: 5 minutes

Psychostimulants are first-line treatments for ADHD. However, some patients may be resistant to treatment or may not tolerate stimulants.

Alpha-2 adrenergic agonists, guanfacine and clonidine can be valuable as monotherapy or augmentation agents in ADHD.

Both clonidine and guanfacine stimulate Alpha-2 adrenergic receptors pre and post-synaptically.


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