Complex Interaction Between Genetics, Immune System and The Brain – Origin of Schizophrenia

Posted on:May 11, 2016
Last Updated: November 24, 2023
Time to read: 4 minutes

A landmark study into the origin of schizophrenia has published a causal link between a gene related to synaptic pruning in the brain and risk of schizophrenia. Researchers from the Broad Institute’s Stanley Center for Psychiatric Research and Harvard University explain that it is inherited variants of a gene associated with synaptic pruning—the reduction of connections between neurons—that increase a person’s risk of developing schizophrenia. The study was published in Nature in January 2016 and details more than 100 regions in the human genome that carry an increased risk of developing schizophrenia.


Biological Insights from Genetic Loci
Ripke, S., Neale, B. M., Corvin, A., Walters, J. T., Farh, K. H., Holmans, P. A., … & Pers, T. H. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421.
Immunology of Schizophrenia
Mueller, N. (2014). Immunology of schizophrenia. Neuroimmunomodulation, 21(2-3), 109-116.