Autoimmune Diseases Masquerading as Psychiatric Disorders – A Paradigm Shift
The first description of an autoimmune disease affecting the brain was provided by William Osler in 1895 where he described the occurrence of psychosis in SLE. It hasn’t been until more recently that this hypothesis has gathered some momentum in neurology and psychiatry.
Osler, W. (1895). On the Visceral Complications Op Erythema Exudativum Multiforme. The American Journal of the Medical Sciences, 110(6), 629-645.
Rege, S., & Hodgkinson, S. J. (2013). Immune dysregulation and autoimmunity in bipolar disorder: Synthesis of the evidence and its clinical application. Australian and New Zealand Journal of Psychiatry.