Prof Graham Hughes Introduces You To The World of Lupus and Antiphospholipid Syndrome – Prof Graham Hughes

Posted on June 9, 2016

Prof. Graham Hughes trained at the London Hospital and spent two years with Prof. Charles Christian in New York working on the introduction of the anti-DNA assay. He set up Europe’s first dedicated Lupus clinic in 1971 and described the Antiphospholipid syndrome / Hughes Syndrome in 1983.  He is founder and editor of the International Journal Lupus, now in its 20th year. Prof Hughes has published widely in Lupus and connective tissue diseases and published 12 books. He is head of the London Lupus Centre at London Bridge hospital in London. He delivers an introduction to two diseases: Lupus and Hughes Syndrome (antiphospholipid syndrome, APS). Future videos will showcase these diseases in more detail.

  1. Osler was the first clinician to put Lupus on the map in 1895 – “….of unknown aetiology….skin lesions, arthritis, gastrointestinal crises, endocarditis, pericarditis, acute nephritis….recurrence is a special feature of the disease…”
  2. “So doctor, do you have any patients with hair loss, fatigue, rashes, recurrent Glandular Fever and/or M.E? These are all symptoms of Lupus”
  3. In order to test for Lupus, Prof. Hughes suggests that you tick three boxes: 1. ANA, 2. DNA (absolute) and 3. Anticardiolipin (aCL) (For the antiphospholipid syndrome)

Video of a clinical case of Antiphsopholipid syndrome with neuro-psychiatric manifestations. 

  • Marco Haamans

    Thanks you for this great information!✋