The etiopathogenesis of alcoholism involves a complex interplay between biological, psychological and socio-environmental factors. However, one of the strongest predictors is the genetic disposition of an individual, with heritability estimated to range between 50% and 64% of cases. Variation in genes encoding enzymes involved in… Read More »
Prof Michael Berk talks about the application of NAC in addiction, autism, OCD and traumatic brain injury. NAC and Addiction In addiction, you have a situation where glial glutamate uptake is via a transporter called Glutamate Transporter 1 (GLT1) and drug abuse down regulates this… Read More »
Researchers used male Lister Hooded rats that underwent functional disconnections (by excitotoxic lesions) of the amygdala-striatal networks, combined with cocaine self-administration training sessions. Measurements at different stages (early, intermediate and late) of goal-directed, cue-controlled cocaine-seeking behaviour were analysed to understand the effect of disconnections on… Read More »
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