Wernicke-Korsakoff Syndrome with Serum Positive Anti-NMDA-Receptor Antibodies – Case Files

Posted on October 30, 2016

Anti-NMDA-receptor antibody (Anti-NMDA-R ab) encephalitis is an important differential diagnosis of psychosis, being first demonstrated in young women with ovarian teratomas. Anti-NMDA-R abs, however, have been shown to be present in the serum of patients with neurodegenerative disorders such as Creutzfeldt-Jakob disease as well as schizophrenia (Greta-Arribas, Titulaer, Torrents et al. 2014). This case highlights the interesting dilemma of a patient who presented with alcohol-related brain damage but had serum Anti-NMDA-R abs and an ovarian cyst.

Reference

Diagnosis and significance of antibody titers in anti-NMDA receptor encephalitis

Gresa-Arribas N, Titulaer MJ, Torrents A, et al. Diagnosis and significance of antibody titers in anti-NMDA receptor encephalitis, a retrospective study. Lancet neurology. 2014;13(2):167-177. doi:10.1016/S1474-4422(13)70282-5.