A Focus on Vortioxetine – Mechanism of Action and Efficacy
Vortioxetine is an atypical antidepressant with multimodal activity. It is a serotonin modulator and stimulator because although it has SERT inhibition properties, it is also a serotonin receptor agonist and antagonist.
It also exerts effects on norepinephrine, dopamine, glutamate, GABA, and the cholinergic system.
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Boulenger J et al., Efficacy and safety of vortioxetine (Lu AA21004), 15 and 20 mg/day: a randomized, double-blind, placebo-controlled, duloxetine-referenced study in the acute treatment of adult patients with major depressive disorder. International Journal of Clinical Psychopharmacology. 2014