Your Quick Guide to Ketamine in Depression and a Study That Questions It’s Known Mechanism of Action

Posted on July 15, 2016

Unipolar major depressive disorder (MDD) affects approximately 350 million people worldwide with almost one-third of patients not responding to existing anti-depressants. Indeed, most antidepressants take weeks or months to achieve a significant effect thus highlighting a clear unmet need for rapid-acting and effective treatments.

Reference

Ketamine in Depression

Zanos et al., NMDAR inhibition – independent antidepressant actions of ketamine metabolites, Nature (533), 481-486, 2016

Ketamine Infusions in Depression
Murrough, J. W., Perez, A. M., Pillemer, S., Stern, J., Parides, M. K., aan het Rot, M., … & Iosifescu, D. V. (2013). Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biological psychiatry, 74(4), 250-256.
Ketamine in Depression

Arunogiri, S., Keks, N. A., & Hope, J. (2016). Should ketamine be used for the clinical treatment of depression?. Australasian Psychiatry,