How to Treat Depression by Using Biological Deconstruction – Case Files of a Patient with OCD and Depression

Posted on September 11, 2016

Jane Doe, a 48-year-old accountant with a 30-year history of Obsessive-Compulsive Disorder (OCD) mainly related to checking behaviour presents with a worsening of mental state. She has been on Sertraline 300 mg OD for the last 20 years and been well controlled.

What led to the deterioration and how was the patient treated? The case highlights the importance of avoiding a reductionistic approach and using deconstruction of the mental health disorder in formulation and management.


Stahl's Psychopharmacology
Stahl, S. M. (2013). Stahl’s essential psychopharmacology: neuroscientific basis and practical applications. Cambridge university press.
Brain White-Matter Hyperintensities and Major Depressive Disorder

Iosifescu, D. V., Renshaw, P. F., Lyoo, I. K., Lee, H. K., Perlis, R. H., Papakostas, G. I., … & Fava, M. (2006). Brain white-matter hyperintensities and treatment outcome in major depressive disorder. The British Journal of Psychiatry, 188(2), 180-185.

The Clinical Importance of White Matter Hyperintensities
Debette, S., & Markus, H. S. (2010). The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. Bmj, 341, c3666.
  • Huu Kim Le

    Great article. The diagrams are very impressive. Thanks Sanil.

    • PsychScene Hub

      Thanks ! Appreciate it.