How to Treat Depression by Using Biological Deconstruction – Case Files of a Patient with OCD and Depression
Jane Doe, a 48-year-old accountant with a 30-year history of Obsessive-Compulsive Disorder (OCD) mainly related to checking behaviour presents with a worsening of mental state. She has been on Sertraline 300 mg OD for the last 20 years and been well controlled.
What led to the deterioration and how was the patient treated? The case highlights the importance of avoiding a reductionistic approach and using deconstruction of the mental health disorder in formulation and management.
Iosifescu, D. V., Renshaw, P. F., Lyoo, I. K., Lee, H. K., Perlis, R. H., Papakostas, G. I., … & Fava, M. (2006). Brain white-matter hyperintensities and treatment outcome in major depressive disorder. The British Journal of Psychiatry, 188(2), 180-185.